The Chelsea manager could also include Thiago Silva against the Seagulls after he was forced off with a back problem in the FA Cup semi-final win over Manchester City.
Tuchel, however, is wary of how much game time the Brazilian has had to play and does not want to overload the veteran defender.
Matteo Kovacic remains the only absentee ahead of the game, with the midfielder still suffering from a hamstring problem.
Asked about team news ahead of the game, Tuchel said: "I expect Andreas to be back and available.
"Thiago it is a bit different, but because of acute overload. He is not injured so we have to take care of his overload. I think and hope that it is only Kova that we have out with injury."
Midfielder Mateo Kovacic remains sidelined with hamstring trouble, while defender Thiago Silva could take a seat on the bench after featuring twice last week.
Striker Aaron Connolly could return to Brighton’s squad following a foot injury. The Republic of Ireland international has not featured since the 1-0 defeat to West Brom on February 27 but has trained freely during the past week.
Defender Tariq Lamptey (hamstring) and winger Solly March (knee) remain sidelined for Albion.
Brighton provisional squad: Sanchez, Steele, White, Webster, Dunk, Veltman, Burn, Karbownik, Bissouma, Gross, Lallana, Propper, Caicedo, Mac Allister, Alzate, Moder, Jahanbakhsh, Izquierdo, Trossard, Maupay, Welbeck, Zeqiri, Tau, Connolly.
Chelsea vs Brighton prediction
Following their FA Cup semi-final win over Man City, Chelsea should be buzzing. Tuchel has an incredibly deep squad with which to rotate, and given their record against Brighton, this should be fairly straightforward for Chelsea.